The bus collided with a Honda Accord on Brass Castle Road in White Township just before 3:55 p.m., Sgt. Alejandro Goez told Daily Voice.
The woman driving the Honda was extricated and taken to a nearby hospital for treatment of non-life-threatening injuries, Goez said.
The school bus driver and passenger were unharmed.
The scene was cleared by around 5 p.m., Goez said.
The crash remained under investigation. No further details were released.
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